ASSESSMENT OF CRP IN PATIENTS WITH TYPHOID FEVER
Keywords:
Typhoid fever, CRP, Salmonella, Seropositivity, Gastrointestinal, FibrileAbstract
A total of seventy-nine cases of patients with age range 1-75 suffering from intestinal disturbance suspected to be Typhoid infected examined during the period between October / 2025 to January / 2026, patients were attending an outpatient clinic in AL-Najaf province, Iraq. The present data indicated that the prevalence of 79 febrile cases was insignificantly higher (P=0.36) among females (41, 1.9%) and significantly elevated (P=0.001) in the 1-15 year age bracket (27.8%), but for Salmonella, individuals aged 61-75 exhibited a considerable susceptibility (P=0.001). Nevertheless, 23 (29.2%) of the feverish patients tested positive for typhoid, whereas the CRP positivity rates were 29.2% for general febrile individuals and 5.1% for those with positive Salmonella. The CRP distribution was markedly (P=0.04) elevated in females compared to males. Seropositivity for Salmonella and CRP in febrile patients was comparable at 29.2%, although the incidence of acute salmonella infection was 5.1%.
References
Aljanaby AAJ, Alhasnawi HMRJ. Phenotypic and molecular characterization of Klebsiella pneumoniae isolated from different clinical infections in Al-Najaf Province-Iraq. Iraqi J Sci. 2017;58(3B):1508-1519. doi:https://doi.org/10.24996/ijs.2017.58.3B.15
Teferi MY, El-Khatib Z, Alemayehu EA, Adane HT, Andualem AT, Hailesilassie YA, et al. Prevalence and antimicrobial susceptibility level of typhoid fever in Ethiopia: A systematic review and meta-analysis. Prev Med Rep. 2021;23:101670. doi:https://doi.org/10.1016/j.pmedr.2021.101670
Galgallo DA, Roka ZG, Boru WG, Abill K, Ransom J. Investigation of a typhoid fever epidemic in Moyale sub-county, Kenya, 2014-2015. J Health Popul Nutr. 2018;37(1):5. doi:https://doi.org/10.1186/s41043-018-0132-z
Masuet-Aumatell C, Atouguia J. Typhoid fever infection-antibiotic resistance and vaccination strategies: A narrative review. Travel Med Infect Dis. 2021;40:101946. doi:https://doi.org/10.1016/j.tmaid.2020.101946
Brockett S, Wolfe MK, Hamot A, Appiah GD, Mintz ED, Lantagne D. Associations among water, sanitation, and hygiene, and food exposures and typhoid fever in case-control studies: A systematic review and meta-analysis. Am J Trop Med Hyg. 2020;103(3):1020-1031. doi:https://doi.org/10.4269/ajtmh.19-0814
Nassir KF, Ali BM, Ibrahim ZH, Qasim ZJ, Mahdi SG, Mustafa NM, et al. Prevalence and antimicrobial resistance profile of Salmonella Typhi infection in Iraq, 2019-2021. Med J Malaysia. 2024;79(1):74-79. (coalitionagainsttyphoid.org)
Szalai AJ, VanCott JL, McGhee JR, Volanakis JE, Benjamin WH Jr. Human C-reactive protein is protective against fatal Salmonella enterica serovar Typhimurium infection in transgenic mice. Infect Immun. 2000;68(10):5652-5656. doi:https://doi.org/10.1128/IAI.68.10.5652-5656.2000
Choo KE, Davis TM, Henry RL, Chan LP. Serum C-reactive protein concentrations in Malaysian children with enteric fever. J Trop Pediatr. 2001;47(4):211-214. doi:https://doi.org/10.1093/tropej/47.4.211
Moutachakkir M, Lamrani Hanchi A, Baraou A, Boukhira A, Chellak S. Immunoanalytical characteristics of C-reactive protein and high sensitivity C-reactive protein. Ann Biol Clin (Paris). 2017;75(2):225-229. doi:https://doi.org/10.1684/abc.2017.1232
Srikantiah P, Girgis FY, Luby SP, Jennings G, Wasfy MO, Crump JA, et al. Population-based surveillance of typhoid fever in Egypt. Am J Trop Med Hyg. 2006;74(1):114-119. PMID:16407354. (scholars.duke.edu)
Allu MA, Assafi MS, Polse RF, Al-Berfkani MI. Present status of Salmonella Typhi in different age groups hospitalized patients in Duhok City, Iraq. Zanco J Pure Appl Sci. 2019;31(6):123-129. doi:https://doi.org/10.21271/zjpas.31.6.13 (doaj.org)
Asreah R, Atta S, SarKo S. Clinical characteristics and antibiotics sensitivity of culture positive typhoid fever patients in Baghdad Teaching Hospital: A single center study. Open Access Maced J Med Sci. 2022;10(B):1846-1850. doi:https://doi.org/10.3889/oamjms.2022.10489
Ishtiaq A, Khalil S, Khalil S, Ahmed F, Ahmad B, Ghaffar A, et al. Prevalence of typhoid fever among different socio-demographic groups in District Bahawalnagar, Pakistan. Pak J Health Sci. 2023;4(1):138-143. doi:https://doi.org/10.54393/pjhs.v4i01.521
Kumar MS, Vivek GS, Prashanth HV, Rao PM, Nagaraj ER. Comparison of Salmonella Typhi and Salmonella Paratyphi A occurrence in a tertiary care hospital. J Clin Diagn Res. 2013;7(12):2724-2726. doi:https://doi.org/10.7860/JCDR/2013/6719.3716
Lee JH, Kim J, Kim K, Jo YH, Rhee JE, Suh GJ, et al. Procalcitonin and C-reactive protein as diagnostic biomarkers for bacterial gastroenteritis: A retrospective analysis. J Clin Med. 2025;14(7):2135. doi:https://doi.org/10.3390/jcm14072135
Crump JA, Sjölund-Karlsson M, Gordon MA, Parry CM. Epidemiology, clinical presentation, laboratory diagnosis, antimicrobial resistance, and antimicrobial management of invasive Salmonella infections. Clin Microbiol Rev. 2015;28(4):901-937. doi:https://doi.org/10.1128/CMR.00002-15
Evans SS, Repasky EA, Fisher DT. Fever and the thermal regulation of immunity: the immune system feels the heat. Nat Rev Immunol. 2015;15(6):335-349. doi:https://doi.org/10.1038/nri3843
Klein SL, Flanagan KL. Sex differences in immune responses. Nat Rev Immunol. 2016;16(10):626-638. doi: https://doi.org/10.1038/nri.2016.90
Khan D, Ansar Ahmed S. The immune system is a natural target for estrogen action: Opposing effects of estrogen in two prototypical autoimmune diseases. Front Immunol. 2016;6:635. doi.org/10.3389/fimmu.2015.00635.
Tsilidis KK, Rohrmann S, McGlynn KA, Nyante SJ, Lopez DS, Bradwin G, et al. Association between endogenous sex steroid hormones and inflammatory biomarkers in US men. Andrology. 2013;1(6):919-928. doi: 10.1111/j.2047-2927.2013.00129.x. PMID: 24124163; PMCID: PMC3812341. (pmc.ncbi.nlm.nih.gov)
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